Best NFL Against the Spread Picks & Odds for Week 13

⭐ Best Bet: Chargers -5.5 (-110) at FanDuel

The Patriots quarterback situation remains a mess. Mac Jones started last week against the New York Giants but was pulled after completing just 12 of 21 passes for 89 yards and two interceptions. It was the second straight week Jones was pulled for backup Bailey Zappe, and Zappe wasn't able to rally the Patriots to victory. 

Considering the mess of New England's offense, we're going with Chargers -5.5 (-110) at FanDuel. The Patriots have scored just 13 points combined in the last two weeks. New England is 31st in points per game (13.5) and essentially has nothing left to play for this season. 

At least the Chargers have a shot at salvaging their season. Los Angeles has the eighth-best scoring offense in the league (24.5) and should be able to put up enough points to cover this spread and win by a touchdown. 

Best Betting Pick:  Chargers -5.5 (-110) at FanDuel

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⭐  Best Bet: Steelers -5.5 (-110) at BetMGM

All those calling for former Steelers offensive coordinator Matt Canada to be fired sooner were validated last week. The Steelers defeated the Cincinnati Bengals 16-10 and racked up 421 yards, snapping a streak of 58 games without gaining at least 400 yards. 

With a reinvigorated Steelers offense, we're going to take Steelers -5.5 (-110) at BetMGM against a struggling Cardinals team. Pittsburgh quarterback Kenny Pickett threw for a season-high 278 yards in the win over the Bengals as running backs coach Eddie Faulkner ran the offense. Running back Najee Harris was also effective with 99 yards and a touchdown, averaging 6.6 yards per carry. 

The Cardinals effectively no-showed last week against the Rams, getting steamrolled 37-14 at home. Arizona gave up 457 yards, including 228 yards on the ground. At 2-10, the Cardinals seem ready to mail it in, so we're going to back the thriving Steelers. 

Best Bet: Steelers -5.5 (-110) at BetMGM

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⭐ Broncos +3.5 (-118) at FanDuel

The Broncos appeared doomed for mediocrity after a 1-5 start, but somehow, Denver has turned it around, winning its last five games. The Broncos defeated Kansas City's Patrick Mahomes and Buffalo's Josh Allen during their win streak, showing it can defeat the top quarterbacks in the league. 

We like Broncos +3.5 (-118) at FanDuel against the Texans. Denver's season stats are skewed because of its horrible start and the 70 points it surrendered to the Dolphins, but the Broncos have played better as of late, giving up just 20 points per game. Offensively, the Broncos have found their identity as a strong run team. Denver ranks eighth in the league in yards per rush (4.4). 

Denver should also have success against a bad Texans secondary. Houston ranks 27th in passing yards allowed per game (252.5) and 28th in yards allowed per pass (7.3). Given Denver's strengths and its recent run, we'll gladly take the +3.5 against Houston. 

Best Betting Pick:  Broncos +3.5 (-118) at FanDuel

⭐  Best Bet: 49ers -2.5 (-114) at BetMGM

The game of the week features the San Francisco 49ers traveling to Philadelphia to take on the Eagles in a rematch of last season's NFC Championship. Revenge will be on the mind for the 49ers after having to play last year's game essentially without a quarterback with Brock Purdy suffering an arm injury and Josh Johnson getting knocked out due to a concussion. 

We're going with 49ers -2.5 (-114) at BetMGM. It seems ridiculous to fade a 10-1 Eagles team at home, but the reality is the Eagles have outperformed what they'e shown on the field this season. Philadelphia has been outgained by at least 98 yards in each of its last four games and somehow came out victorious in each contest. 

The Eagles are also 7-1 in one-score games, and some negative regression is coming at some point. In addition to the motivational edge San Francisco has, the 49ers are playing as one of the best teams in the league. San Francisco is No. 1 in defensive adjusted value over adjustment and also has the top-ranked passing attack. 

Give us the 49ers on the road. 

Best Bet:  ⭐ 49ers -2.5 (-114) at BetMGM

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⭐ Best Bet: Packers +6 (-110)  at FanDuel

Jordan Love has started to look like a franchise quarterback for the Packers. Over the last three weeks, he's thrown for at least 260 yards in each game and has passed for seven touchdowns to just two interceptions. He ranks inside the top five in success rate and expected points added, making him one of the top-performing quarterbacks. 

We're going to take Packers +6 (-110)  at FanDuel. Green Bay will have the rest advantage after having played on Thanksgiving the previous week Key defenders such as Jaire Alexander and DeVondre Campbell should be back, in addition to running back Aaron Jones. 

We've seen the Chiefs struggle recently, notably in losses to the Broncos and Eagles in recent weeks, so we're going to take the surging Packers at home who have the rest and health advantages. 

Best Betting Pick:  Packers +6 (-110)  at FanDuel