Colorado vs. Oregon Prediction, Odds & Week 4 Best College Football Bets

• Date:  Saturday, September 23, 3:30 PM EDT
• Location: Autzen Stadium in Eugene, Oregon 
• TV: ESPN
• My best bet: ⭐ Colorado +21 (-110) at BetMGM

Plenty of attention will be on the absence of Colorado's Travis Hunter. The five-star recruit is Colorado's best wide receiver and cornerback, and without him, Colorado will have to compensate for his absence with other players stepping up. But the Buffaloes have shown they can play inspired football with the Week 1 win over TCU as a 21-point underdog. But Oregon will be Colorado's biggest challenge yet. 

We're still going with Colorado +21 (-110) at BetMGM. We have yet to see Oregon play a top team this season. The only impressive win was at Texas Tech and was a one-point game before a late pick-six. Oregon's other two wins came against Portland State and Hawaii, who no one is going to confuse for Alabama or LSU. Texas Tech hasn't exactly put together the best resume either, with a loss to Wyoming this season. 

The Buffaloes may be lucky to get more than a few defensive stops, but its offense has the potential to keep them within 21 points. With Colorado's passing attack, a backdoor cover is also in play if the team is down by 27 points or less down the stretch. 

⭐  Colorado +21 (-110) at BetMGM

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⭐ Over 70.5 (-110) at FanDuel 

There's a reason this is the highest point total posted so far in this college football season. Oregon has games of 81, 38 and 55 points, while Colorado has gone off for 45, 36 and 43 points in its three contests. The Ducks are the second-highest-scoring team in the country, averaging 58 points per game and fourth in yards per game (579). 

When you consider the uptempo pace each team plays with, we like the over of 70.5 (-110) at FanDuel. Colorado will be missing Hunter, so Oregon and Bo Nix should have no issues moving the ball through the air. 

Colorado's Shedeur Sanders is also expected to air it out. He's second in the country in passing yards with 1,251 through three games. More passes from both teams should result in a high-scoring game with incomplete passes stopping the clock and prolonging the game. Both teams will look to outscore each other and we wouldn't be surprised to see this game end up in the 80s. 

⭐ Recommended Bet: Over 70.5 (-110) at FanDuel 

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⭐ Troy Franklin Anytime Touchdown Scorer (-225) at BetMGM

Colorado's pass defense is suspect. The Buffaloes surrendered 397 passing yards and four touchdowns to Colorado State and two touchdowns to TCU. Its pass defense could be even worse this weekend without top cornerback Travis Hunter sitting out. 

For a player prop bet on the Colorado vs. Oregon game, we're going with Troy Franklin anytime touchdown scorer (-225) at BetMGM. Franklin is Oregon's leading receiver this season with 17 catches for 292 yards and three touchdowns. Just last week Colorado surrendered four touchdown receptions to three different receivers who each tallied over 100 reception yards. 

Oregon has similar depth at wide receiver, which won't allow Colorado to hone in on Franklin. With Hunter out, expect Franklin to break free for at least one touchdown against Colorado. 

⭐  Troy Franklin Anytime Touchdown Scorer (-225) at BetMGM

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