NFL Week 13 Picks Against the Spread, Predictions & NFL Best Bets

⭐ Philadelphia Eagles +2.5 (-100) at BetMGM

The Eagles secured a narrow overtime win against the Bills, 37-34, triumphing as three-point favorites, though it wasn't the prettiest of wins. 

Quarterback Jalen Hurts continued his record-breaking streak, leading Philadelphia to its eighth straight comeback win from a double-digit deficit, a feat unmatched by any other quarterback in the league's history.

 Hurts has an impressive track record, winning 12 out of his last 13 regular-season home games since the start of the 2022 season.

A key concern for the Eagles is the fitness of right tackle Lane Johnson. The 2013 fourth overall draft pick missed the last game due to groin soreness and remains questionable. 

His absence could be significant, especially against the formidable 49ers defensive line, which includes Nick Bosa, Arik Armstead, Chase Young, and ex-Eagle Javon Hargrave.

Nevertheless, the opportunity to back the Eagles as underdogs in their home stadium, especially in a rematch of the NFC title game, seems too enticing to overlook, even if Johnson is unavailable.

⭐ ATS Pick: Philadelphia Eagles +2.5 (-100) at BetMGM

⭐ Tampa Bay Buccaneers -5 (-110) at FanDuel

Carolina's performance against the spread has been dismal this season, with a record of just 1-8-2, and they've notably failed to cover in any of their road games (0-5-1).

Despite not covering the spread in their recent 27-20 defeat to the Colts in Week 12, the Buccaneers have maintained a more positive record against the spread in 2023, standing at 7-4. 

Tampa Bay has been particularly strong in recent matchups, covering in four of their last five games, and they have a dominant track record in their divisional games against Carolina, winning seven out of the last ten encounters, including three consecutive wins at Raymond James Stadium.

Even with the Panthers possibly rejuvenated by the recent dismissal of head coach Frank Reich following their 17-10 loss in Week 12, their chances against Tampa Bay seem slim. 

This is despite Tampa Bay's struggles, as they have lost six of their seven games since their Week 5 bye.

⭐ ATS Pick: Tampa Bay Buccaneers -5 (-110) at FanDuel

⭐ Miami Dolphins -9.5 (-110) at Draftkings

Washington struggled significantly in their recent loss to the Cowboys on Thanksgiving. Despite returning home with an extended break of 10 days, it seems wise to bet against the Commanders in their next matchup.

The Dolphins, on the other hand, are riding high from a convincing 34-13 win over the Jets, marking the NFL's inaugural Black Friday game. They also hold a solid 3-2 record against the spread in away games.

This appears to be a clear mismatch, with Miami's high-scoring offense facing Washington's struggling defense. 

The Dolphins boast an impressive average of 30.8 points per game, the second-highest in the NFL, while the Commanders' defense has been the most generous in the league, allowing 29.2 points per game.

Although it may seem risky to back Miami with a substantial spread in an away game in December, the Dolphins' prospects look promising. 

They face a Washington defense that has allowed 29 or more points in four of their last five games, indicating a strong likelihood for Miami to cover the large spread.

⭐ ATS Pick: Miami Dolphins -9.5 (-110) at Draftkings