Tennessee Titans at Indianapolis Colts Odds, Predictions & NFL Week 5 Picks

• Date: Sunday, Oct. 8, 2023, 1:00 p.m. EDT
• TV: CBS
• My Best Bet: Titans Moneyline (-110) FanDuel

It's been an interesting season for the Tennessee Titans. They've won a close game, beating the Los Angeles Chargers in overtime, 27-24, and also lost a tight one, falling to the New Orleans Saints 16-15. Then there were the blowouts. Tennessee is coming off a 27-3 win over the Cincinnati Bengals in Week 4, but also lost to the Cleveland Browns by the same score in Week 3. 

⭐ Place Your NFL Best Bets on the Titans vs. Colts Week 5 Matchup NOW! ⭐

Meanwhile, the Indianapolis Colts are also 2-2 and have played two consecutive drama-filled games of their own, beating the Baltimore Ravens in overtime 22-19 before falling to the Los Angeles Rams 29-23. But those two games highlighted a weakness for the Colts. Baltimore gained 186 yards on the ground, averaging 5 yards per carry, while the Rams finished with 164 yards and averaged 4.6 yards per attempt. 

Tennessee is at its best when it can establish the run, as it was able to do so in the win over the Bengals. The Titans ran for 173 yards (5.2) and were led by Derrick Henry gaining 122 yards and a touchdown. We like the Titans in this matchup and expect Henry to have a strong game against the Colts porous run defense.

⭐ My Best Bet: Titans Moneyline (-110) FanDuel

⭐ Derrick Henry Over 75.5 Rushing Yards (-114) at FanDuel

With the Indianapolis Colts recently struggling to top the run, we are going to target Derrick Henry's rushing prop. Henry remains one of the top running backs in the league, and given Tennessee's typical run-focused offense, we know he will get his carries against the Colts. 

We like Derrick Henry Over 75.5 Rushing Yards (-114) at FanDuel. The Colts have allowed the 10th-most rushing yards in the league this year at 507 yards, giving up an average of 126.7 yards per contest. In the two recent games, the Colts allowed 164 rushing yards to the Rams and 186 to the Ravens. 

Henry is coming off one of his best games of the season with 122 yards on 22 carries and had one touchdown and a passing touchdown at the goal line. Henry also ranks second in the league in carries with 73, so he will have plenty of opportunities to clear this prop. 

⭐ Best Betting Pick: Derrick Henry Over 75.5 Rushing Yards (-114) at FanDuel

⭐ Anthony Richardson Over 45.5 Rushing Yards (-114) at FanDuel

One of Anthony Richardson's traits discussed when he came out of college is his athleticism. He ran a 4.43 40-yard dash at the scouting combine and was projected as one of the top dual-threat quarterbacks in the 2023 NFL Draft class. Through four games, he's flashed that athleticism early on. 

We're going with Anthony Richardson Over 45.5 Rushing Yards (-114) at FanDuel. In two full games he gained a total of 96 rushing yards and had 35 yards on three carries before a concussion forced him out of the game against the Houston Texans. Just last week against the Rams, Richardson ran 10 times for 56 yards. 

In total, Richardson has 12 carries for 131 rushing yards while averaging 5.7 yards per attempt. Considering Richardson cleared this prop number in the last game, was set to before a concussion forced him out in another game and was just six yards short early in the season, we like him to clear this number,

⭐ Best Betting Pick: Anthony Richardson Over 45.5 Rushing Yards (-114) at FanDuel