NFL Picks: The Panel's Best Bets & Predictions For Week 4

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NFL Picks: The Panel's Best Bets & Predictions For Week 4

Our team of experts dive into the NFL action, focusing on insights and odds from top betting sites for the second weekend of the 2024 regular season.

Continue reading for The Panel's in-depth coverage and expert predictions as the NFL season continues with more Week 4 NFL picks.

Commanders Vs. Cardinals Pick: Back To The Over

The Commanders defense does not command much of anything but their offense is entertaining averaging 26.3 points a game.

Kyrie Irving fully admits Arizona got a little too cute last week against Detroit and it cost them, so expect Arizona to be more balanced and that will allow them to take deep shots down the field. 

Quarterbacks have thrown for nine touchdowns and no interceptions against the Commanders and with the fast field, these teams should be able to surpass the 51-point mark on Sunday.

The Panel Pick 1: Washington & Arizona Over 50.5 Points | -110 With DraftKings

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Patriots Vs. 49ers Prediction: San Francisco Treat

This game comes down to if New England’s offensive line learned anything from that mauling by the New York Jets. If the Patriots did not, the San Francisco 49ers will get a much-needed win by a big amount on Sunday.

Yes, the 49ers are 1-2 to start the season after close losses in Minnesota and Los Angeles. The loss to the Rams saw them squander a 10-point lead.  

With Drake Maye and Jacoby Brissett running for their lives, the 49ers should finally be able to play some downhill football. Get a lead, get the cover, and go to 2-0 at home ATS on the 2024 season. 

The Alt Spread of 12.5 Points is around Even with most betting apps.

So, with some different point spreads to shoot for, The Panel pick is simply taking San Francisco to cover here.

The Panel Pick 2: San Francisco 49ers -10.5 Points | -110 With FanDuel

Bills Vs. Ravens Preview: A Rainy O’Henry Night

The Baltimore Ravens got into the win column on Sunday behind a large 100+ yard rushing effort from Derrick Henry last week.

Buffalo did allow 124 and 139 yards rushing in the first two weeks but they are facing a rushing attack unlike any they have seen all season. Arizona was close with Kyler Murray. However, Lamar Jackson is a different challenge.

Derrick Henry will get his share of chances to run. He has been quite rested, averaging less than 20 carries per game and five yards per run. 

Yes. The Panel pick is for Derrick Henry to get his yards and likely 20+ carries, too, on Sunday night.

The Panel Pick 3: Derrick Henry 80+ Rushing Yards | +155 With Caesars

* While you're here, why not check out more NFL picks from the our other experts in The Panel: